breath."
A few more squeals and gasps, a final paroxysm, then the mouse lay dead. Sano and Dr. Ito bowed their heads in respect for the animal that had given its life to the pursuit of scientific knowledge. Then they checked the other cages.
"This mouse is intoxicated, " Dr. Ito said, observing the creature that staggered around the now-empty sake dish, "but otherwise healthy." The shaved animal and the knife-cut one scampered about their cages. "No apparent ill effects here, either." Dr. Ito lifted the cloths off the last two cages, releasing clouds of pungent smoke and revealing two groggy but living mice. "Or here. The ink alone contained poison."
"Could this have been suicide?" Sano asked, still hoping for an easy resolution to Lady Harume's death.
"Possibly, but I think not. Even if she had wanted to die, why choose such a painful method, instead of hanging or drowning herself? Those are the more common means of female suicide. And why bother putting the poison in the ink, instead of simply swallowing it?"
"So Lady Harume was murdered." Dismay tempered Sano's gratification at having his suspicions confirmed. He must report the news to the shogun, the chief castle physician, and palace officials; it would then spread throughout Edo. To prevent destructive consequences, Sano must identify the poisoner, fast. "What substance kills so quickly and horribly?"
"When I was physician to the Imperial Court in Kyoto, I made a study of poisons," Dr. Ito said. "The symptoms caused by this one match those of bish, an extract of a plant native to the Himalayan region. Bish has been used in India and China for almost two thousand years as an arrow toxin, both for hunting and in warfare. As you can see, a small amount introduced into the blood is fatal. People have also died after mistaking the plant's roots for horseradish. But the plant is extremely rare in Japan. I've never heard of any such poisoning cases here."
"Where could the poison that killed Lady Harume have come from?" Sano asked. "Am I looking for a murderer with special knowledge of herbs? Such as a sorcerer, priest, or doctor?"
"Perhaps. But there are druggists who illegally sell poisons to any customer able to pay." Dr. Ito told Mura to remove the mice. Then his expression turned thoughtful. "These merchants usually offer common poisons such as arsenic, which can be mixed with sugar and dusted onto cakes, or antimony, which is administered in tea or wine. Or fugu, the poisonous blowfish.
"But there was one man who became a legend among physicians and scientists: an itinerant peddler who traveled around Japan, collecting remedies from remote areas and in port cities where the locals possess medical knowledge gleaned from foreigners before Japan was closed to free international trade. His name was Choyei, and I used to buy medicine from him when he passed through Kyoto. He knew more about drugs than anyone I've ever met. Mostly he dealt in beneficial substances, though he also sold poisons to scientists who, like myself, desired to study them. And there were rumors that his merchandise had caused the deaths of several high bakufu officials."
"Could he be in Edo now?" Sano asked. If the poison dealer named a recent purchaser of bish, Lady Harume's murder could be solved.
"I haven't seen Choyei-or heard anything of him-in years. He must be about my age now, if he's still alive. An odd, reclusive individual who wandered wherever fancy took him, according to no particular schedule, disguised as a tramp. I heard he was a fugitive from the law."
Though discouraged by this story, Sano didn't lose hope. "If Choyei is here, I'll find him. And there's another possible route to the killer." Sano held up the ink jar. "I'll try to discover where Lady Harume got this, and who could have put poison into it."
"Perhaps the lover for whom she tattooed herself?" Dr. Ito suggested. "Unfortunately, Lady Harume didn't cut his name on her flesh, as courtesans often do, but she would