Here Is a Human Being by Misha Angrist Read Free Book Online

Cliff, 226, 227
    Reif, L. Rafael, 126
n
    Relative Finder (23andMe), 271
    restless legs syndrome, 151
    rheumatoid arthritis, 141–42, 148–49, 151, 258
    Rienhoff, Beatrice, medical genetic condition of, 175–82, 263
    Rienhoff, Hugh, 73, 214, 256, 263, 267
    his genetic testing of daughter Beatrice, 175–88
    RNA (ribonucleic acid), 183n
    Roche (firm), 89, 94
    Roche, Winnie, 25
    Rose, Nikolas, 234
    Rosenbaum, Abraham, 261
    Rothberg, Jonathan, 85, 86, 87, 88, 277
    Rubin, Vera, 233
    Sabeti, Pardis, 77
    Sanger, Fred, DNA sequencing method of, 80–82, 83, 85
    Sanger Institute, 85, 87
    schizophrenia, 242
    Schloss, Jeff, 159, 160
    Schwartz, Sheila, 120
    Sciona (firm), 121–23
    Secretary’s Advisory Committee on Genetics, Health, and Society
    (SACGHS), 68–72, 168
    SEQ (firm), 91
    Sequence Variant Analyzer, 252, 256, 258
    Sequoia Capital (firm), 62
    Shendure, Jay, 90, 93, 136
    Sherley, James
    as Personal Genome Project subject, 123–32, 166, 203, 206, 207
    stem cell research, 124, 125, 126, 130–31
    tenure dispute with MIT, 124–29
    Shianna, Kevin, 96, 241, 277
    sequencing of author’s DNA by, 243–51, 263–67
    sickle-cell anemia, 214
    Single Molecule Real Time (SMRT)
    DNA sequencing system, 229–32
    Smith, Gordon, 121, 122
    Smith, Jason, 250–51
    Smithies, Oliver, 15
    SMRT.
See
Single Molecule Real Time (SMRT) sequencing system
    SNPedia, 140–42, 145–49, 204, 242, 245, 246, 256–57, 258
    SNPs (single nucleotide polymorphisms), 55, 58, 75, 141–43, 145
    Social networking, 1, 57, 118–19
    Solexa (firm), 89, 92, 95, 193, 197
    SOLiD DNA sequencer, 79, 83, 193, 194, 281
    Spas, 113
    sperm donation industry, 103–10
    spliced genes, 258
    Stefansson, Kari, 70, 232, 281, 282
    stem cells, James Sherley’s research on, 124, 125, 126, 130–31
    Stephan, Dietrich, 60–68, 69, 70, 73, 74, 75, 149, 232, 281
    Strong, Virginia Anne, 16
    Sullivan, John, 95
    Sweeney, Latanya, 19
    Synthetic biology, 223–24
    Tay-Sachs disease, 6, 274
    Terry, Rich, 192–93
    Thakuria, Joe, 201–204, 205, 257, 259
    Thompson, Tommy, 68
    Trait-o-matic software, 256–58, 261–63, 264
    traits, 14, 21, 56, 57
    transforming growth factor beta (TGF)
    pathway, 178, 179, 181
    Translational Genomics Research Institute (TGen), 61, 74
    trimethylaminuria, 205
    Triple-A syndrome, 187
    tuberculosis, 203, 205
    Turner, Steve, 229–32
    23andMe (firm), 63, 68, 69, 70, 72, 100, 112, 122, 123n, 168, 281, 282
    author’s genetic test from, 214, 257
    history, services of, 54–60, 74, 76, 118, 118
n,
214, 216, 242, 271
    U.S. Food and Drug Administration (FDA), 115–16, 120, 282
    U.S. military, 4, 124
    Valle, David, 177–78
    variome, 55
    Venter, Craig, 18, 44, 60, 73, 82, 83, 91, 92, 135, 223, 254
    genome sequence of, 18n, 22, 39
    VisiGen (firm), 97
    Vogelstein, Bert, 90
    Vorhaus, Dan, 24
    Walmart, 3–4
    warfarin (pharmaceutical drug), 115–16, 199, 245
    Watson, James (Jim), 41–44, 46–49, 224
    APOE gene status, 27n, 41, 47, 48, 52, 138–40, 209
    genome sequencing of, 18n, 22, 36, 39, 42–44, 47, 254, 263
    Watson, Rufus, 22
    Weld, William, 20
    Wikipedia, 145, 146
    Wojcicki, Anne, 57, 59–60, 75
    Wu, Marie, 52, 102, 223
    Wu, Ting, 16, 17, 49, 102, 162, 202–4, 222
    X Prize, 83–84, 224, 229
    X Prize Foundation, 83–84
    Y-chromosome, 57, 241, 270
    Zaranek, Sasha, 209–10

Acknowledgments
    The book you hold in your hands or on your screen could not have happened without the extraordinary generosity of countless loved ones, friends, colleagues, and strangers. I will try to count them anyway.
    I am eternally grateful to George Church for allowing me to shadow him for four years and never once telling me to go away, even though I gave him ample justification to do so on many occasions.
    I thank Hunt Willard for his seemingly limitless supply of faith and patience. I don’t know many people who could say that about their bosses. I have been blessed for many years in this regard.
    I am deeply indebted to David Goldstein, not only for agreeing to sequence me, but