Cliff, 226, 227
Reif, L. Rafael, 126
n
Relative Finder (23andMe), 271
restless legs syndrome, 151
rheumatoid arthritis, 141–42, 148–49, 151, 258
Rienhoff, Beatrice, medical genetic condition of, 175–82, 263
Rienhoff, Hugh, 73, 214, 256, 263, 267
his genetic testing of daughter Beatrice, 175–88
RNA (ribonucleic acid), 183n
Roche (firm), 89, 94
Roche, Winnie, 25
Rose, Nikolas, 234
Rosenbaum, Abraham, 261
Rothberg, Jonathan, 85, 86, 87, 88, 277
Rubin, Vera, 233
Sabeti, Pardis, 77
Sanger, Fred, DNA sequencing method of, 80–82, 83, 85
Sanger Institute, 85, 87
schizophrenia, 242
Schloss, Jeff, 159, 160
Schwartz, Sheila, 120
Sciona (firm), 121–23
Secretary’s Advisory Committee on Genetics, Health, and Society
(SACGHS), 68–72, 168
SEQ (firm), 91
Sequence Variant Analyzer, 252, 256, 258
Sequoia Capital (firm), 62
Shendure, Jay, 90, 93, 136
Sherley, James
as Personal Genome Project subject, 123–32, 166, 203, 206, 207
stem cell research, 124, 125, 126, 130–31
tenure dispute with MIT, 124–29
Shianna, Kevin, 96, 241, 277
sequencing of author’s DNA by, 243–51, 263–67
sickle-cell anemia, 214
Single Molecule Real Time (SMRT)
DNA sequencing system, 229–32
Smith, Gordon, 121, 122
Smith, Jason, 250–51
Smithies, Oliver, 15
SMRT.
See
Single Molecule Real Time (SMRT) sequencing system
SNPedia, 140–42, 145–49, 204, 242, 245, 246, 256–57, 258
SNPs (single nucleotide polymorphisms), 55, 58, 75, 141–43, 145
Social networking, 1, 57, 118–19
Solexa (firm), 89, 92, 95, 193, 197
SOLiD DNA sequencer, 79, 83, 193, 194, 281
Spas, 113
sperm donation industry, 103–10
spliced genes, 258
Stefansson, Kari, 70, 232, 281, 282
stem cells, James Sherley’s research on, 124, 125, 126, 130–31
Stephan, Dietrich, 60–68, 69, 70, 73, 74, 75, 149, 232, 281
Strong, Virginia Anne, 16
Sullivan, John, 95
Sweeney, Latanya, 19
Synthetic biology, 223–24
Tay-Sachs disease, 6, 274
Terry, Rich, 192–93
Thakuria, Joe, 201–204, 205, 257, 259
Thompson, Tommy, 68
Trait-o-matic software, 256–58, 261–63, 264
traits, 14, 21, 56, 57
transforming growth factor beta (TGF)
pathway, 178, 179, 181
Translational Genomics Research Institute (TGen), 61, 74
trimethylaminuria, 205
Triple-A syndrome, 187
tuberculosis, 203, 205
Turner, Steve, 229–32
23andMe (firm), 63, 68, 69, 70, 72, 100, 112, 122, 123n, 168, 281, 282
author’s genetic test from, 214, 257
history, services of, 54–60, 74, 76, 118, 118
n,
214, 216, 242, 271
U.S. Food and Drug Administration (FDA), 115–16, 120, 282
U.S. military, 4, 124
Valle, David, 177–78
variome, 55
Venter, Craig, 18, 44, 60, 73, 82, 83, 91, 92, 135, 223, 254
genome sequence of, 18n, 22, 39
VisiGen (firm), 97
Vogelstein, Bert, 90
Vorhaus, Dan, 24
Walmart, 3–4
warfarin (pharmaceutical drug), 115–16, 199, 245
Watson, James (Jim), 41–44, 46–49, 224
APOE gene status, 27n, 41, 47, 48, 52, 138–40, 209
genome sequencing of, 18n, 22, 36, 39, 42–44, 47, 254, 263
Watson, Rufus, 22
Weld, William, 20
Wikipedia, 145, 146
Wojcicki, Anne, 57, 59–60, 75
Wu, Marie, 52, 102, 223
Wu, Ting, 16, 17, 49, 102, 162, 202–4, 222
X Prize, 83–84, 224, 229
X Prize Foundation, 83–84
Y-chromosome, 57, 241, 270
Zaranek, Sasha, 209–10
Acknowledgments
The book you hold in your hands or on your screen could not have happened without the extraordinary generosity of countless loved ones, friends, colleagues, and strangers. I will try to count them anyway.
I am eternally grateful to George Church for allowing me to shadow him for four years and never once telling me to go away, even though I gave him ample justification to do so on many occasions.
I thank Hunt Willard for his seemingly limitless supply of faith and patience. I don’t know many people who could say that about their bosses. I have been blessed for many years in this regard.
I am deeply indebted to David Goldstein, not only for agreeing to sequence me, but